Lansdowne Mews was probably laid out in the late 1830s or early 1840s, when the houses south of it in Holland Park Avenue were erected and the section of Ladbroke Road to the north was also being developed. At first it was probably a simple alley between the two sets of gardens, and it seems to have been some time before it became built up. In 1863, according to the Ordnance Survey map, only three of the Holland Park Avenue houses had built themselves stables giving onto the mews at the bottom of their garden. Further stables were gradually added along the south side, with accommodation above. By 1935, there were six numbered dwellings (almost certainly all above stables). The north side, however, remained largely unbuilt up.

By 1871 there was one coachman living in the Mews with his family and three unoccupied premises. By 1901 five families were living in the mews, headed by grooms, stablemen or small tradesmen.

Almost nothing now remains of the old mews. The only 19th century buildings are Nos. 5 and 6, although they are virtually unrecognisable as the stables plus accommodation above that they must once have been. Both have acquired an extra floor and had a major reconfiguration of their facades. There is a flying freehold between No. 5 and No. 6, as the party wall exists at first floor only. At ground floor level there was a narrow alleyway for emergency egress in between the two mews houses, now invisible behind a door.