Keppel Street links Store Street and Gower Street in the west to Malet Street in the east.
The street was developed between 1800 and 1810 by builders including Alexander Hendry and Thomas Lewis
British Museum Avenue was created in the early twentieth century, dividing the street, and replacing Torrington Street, Russell Mews and Keppel Mews South. British Museum Avenue was itself built over in the early 1930s when Senate House and other University of London buildings were constructed on the former eastern end of Keppel Street.
Before the Senate House, it continued on to join Russell Square. The former Royal Institute of Chemistry building, now with a street address of 30 Russell Square, is at what was the eastern end of the street on the north side.