Queen Square was laid out by speculator Nicholas Barbon.
Many of the Queen Square buildings are associated with medicine, particularly neurology.
Queen Square was originally constructed between 1716 and 1725. It was formed from the garden of the house of Sir John Cutler whose last surviving child, Lady Radnor, died in 1697 leaving no issue. It was originally left open to the north for the landscape formed by the hills of Hampstead and Highgate.
The square was previously named Queen Anne’s Square because a statue contained within it was misidentified as depicting Queen Anne. This statue is now believed to be a portrayal of Queen Charlotte, wife of King George III.
The public house on the southwest corner of the square, called "the Queen’s Larder", was, according to legend, used by Queen Charlotte to store food for the king during his treatment for mental illness in a house on the Square.
The church, dedicated to St George the Martyr, was built following public subscription in 1706 before the square was laid out.
Following the trend of nearby areas, gradually the houses were turned into hospitals and other medical institutions.
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